Finally, QFT-GIT assay is currently undergoing a transition to QuantiFERON-TB Gold Plus (QFT-Plus), with a four-sample tube system [26]. However, when our study was designed, QFT-GIT assay was widely used as a reference method; thus, we performed a comparison with QFT-GIT, which has the same three-tube system as the new CLIA-IGRA, to determine the speed and convenience of the new assay for providing acceptable results. Recent comparisons between QFT-GIT assay and QFT-Plus revealed that QFT-Plus shows better sensitivity in detecting recent TB contact [24,27,28]. This is important for determining the relevance of CLIA-IGRA with respect to QFT-Plus in future studies.
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